This article a specific scenario where "Can not send UDP datagram" or "Ignoring SA_CFG since IFF is down" can be seen as symptoms.
juniper> show security ike security-associations
Index State Initiator cookie Responder cookie Mode Remote Address
1 DOWN c5342cfe5b8b22de 0000000000000000 IKEv2 10.10.10.1
These symptoms can be seen if you have both "external-interface" and "local-address" commands in the IKE Gateway config, and the local address specified does not exist in the referenced external interface.
Example:
set interfaces ge-0/0/0.0 family inet address 192.168.0.1/24
set security ike gateway Example-GW external-interface ge-0/0/0.0
set security ike gateway Example-GW local-address 172.16.0.1