Major chassis alarms and service impact is seen after the software upgrade
Major chassis alarms are seen post software upgrade from releases prior to 21.4 (19.4 for example) to 21.4 onwards. "Major Host 0 PCI Device not responding 0x8086:0x154c" "Major Host 1 PCI Device not responding 0x8086:0x154c" NOTE: the alarm can appear on both REs and might take up to 1 minute to appear after the RE comes online.
Power cycle the RE